GBA adaptation of Super Mario Bros. 2 (Super Mario Bros. USA in Japan). Mario, Luigi, Peach and Toad adventure through an incredible fantasy world on a quest to save the day, with little more than vegetables with which to defend themselves. The basic gameplay mechanics are the same in the Game Boy Advance version, but new enemies, better graphics and tougher challenges give the adventure a completely new feel.

Unlike other Mario games where Mario defeats enemies by jumping on their heads, in this game Mario and pals have to pick up items and hurl 'em at their adversaries. Each character has a unique set of strengths and weaknesses, such as Princess Peach's ability to hover longer than any other character. As an added bonus, Super Mario Advance also features the original Mario Bros. game.